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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Regulated mRNA Transport02:22

Regulated mRNA Transport

In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing specific...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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RNA Fluorescence In Situ Hybridization for Long Non-Coding RNA Localization in Human Osteosarcoma Cells
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Cytotopic localization by long noncoding RNAs.

Pedro J Batista1, Howard Y Chang

  • 1Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford, CA 94305, USA.

Current Opinion in Cell Biology
|January 3, 2013
PubMed
Summary
This summary is machine-generated.

Noncoding RNAs are crucial for organizing cellular structures like stress granules and subnuclear bodies. These RNAs act as molecular address codes, ensuring proper cell function and gene regulation.

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Cells exhibit complex organization beyond membrane-bound organelles.
  • Proteins and RNAs form specific intracellular domains, such as stress granules and subnuclear bodies.
  • This organization is vital for cellular processes including signaling and ribosome assembly.

Purpose of the Study:

  • To review evidence highlighting the role of noncoding RNAs in cellular organization.
  • To explore how noncoding RNAs establish and regulate specific cellular domains.
  • To present noncoding RNAs as key regulators of cellular architecture and function.

Main Methods:

  • Review of existing scientific literature and experimental evidence.
  • Analysis of studies investigating the function of noncoding RNAs in cellular compartmentalization.
  • Synthesis of data on RNA's role in forming and maintaining specific protein-RNA domains.

Main Results:

  • Noncoding RNAs are critical for the formation and regulation of cellular domains.
  • These RNAs can be gene-specific and condition-specific, acting as precise molecular markers.
  • RNA's ability to act as a tether facilitates the organization of cellular components.

Conclusions:

  • Noncoding RNAs are essential for establishing and maintaining higher-order organization within cells.
  • RNAs serve as molecular address codes, directing the assembly and function of cellular domains.
  • Understanding noncoding RNA roles is key to comprehending cellular regulation and processes.