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UV filters, ingredients with a recognized anti-inflammatory effect
Céline Couteau1, Catherine Chauvet, Eva Paparis
1Université de Nantes, Nantes Atlantique Universités, MMS, EA 2160, FR CNRS 3473, Nantes, France.
Plos One
|January 4, 2013
Summary
Sunscreen ingredients with anti-inflammatory properties can influence Sun Protection Factor (SPF) determination. This study identified 13 UV filters with significant anti-inflammatory effects, impacting in vivo SPF measurements.
Area of Science:
- Dermatology
- Cosmetic Science
- Pharmacology
Background:
- Observed discrepancies in Sun Protection Factor (SPF) determination between in vivo and in vitro methods prompted investigation.
- A hypothesis was formed regarding the presence of anti-inflammatory ingredients in sunscreens as a contributing factor to these differences.
Purpose of the Study:
- To investigate the anti-inflammatory potential of commercially available UV filters.
- To determine if anti-inflammatory properties of UV filters impact in vivo SPF values.
Main Methods:
- Twenty-one UV filters, authorized by European regulations, were evaluated.
- The phorbol-myristate-acetate (PMA) test was employed using mice to assess anti-inflammatory effects.
- UV filters were tested at various concentrations, including maximum authorized doses, and a dose-response relationship was examined.
Main Results:
- Thirteen out of 21 UV filters exhibited significant anti-inflammatory effects, with edema inhibition exceeding 70%.
- Specific UV filters identified with potent anti-inflammatory activity include diethylhexyl butamido triazone (92%) and benzophenone-5 (90%).
- A clear dose-response relationship was observed for the anti-inflammatory effects of the tested UV filters.
Conclusions:
- The anti-inflammatory properties of sunscreen ingredients can significantly influence in vivo SPF determination.
- Understanding these effects is crucial for accurate SPF assessment and sunscreen formulation.
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