Indications for treatment of recurrent carotid stenosis
K Bekelis1, Z Moses, S Missios
1Section of Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Insights
Indications for re-treating carotid artery stenosis are unclear, with many asymptomatic patients undergoing intervention. This review highlights the need for more rigorous criteria in managing recurrent carotid stenosis.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Neurology
Background:
- Significant variation exists in the criteria for intervention in recurrent carotid artery stenosis.
- Understanding contemporary indications for re-intervention is crucial for patient management.
Purpose of the Study:
- To systematically review and describe the indications for carotid intervention in patients with recurrent stenosis.
Main Methods:
- Systematic review of peer-reviewed studies published between 1990 and 2012.
- Included studies reporting on indications for carotid endarterectomy (CEA) or carotid artery stenting (CAS) after initial intervention for restenosis.
Main Results:
- 50 studies analyzed 3524 patients; most initial interventions were CEA.
- Only 54.7% of patients were treated for symptoms, with just 23.1% of symptomatic patients having documented ipsilateral symptoms.
- Asymptomatic restenosis was treated, often when stenosis exceeded 80%; time to re-intervention varied by cause and procedure type.
Conclusions:
- Current criteria for re-treating carotid stenosis lack rigor.
- Significant ambiguity persists regarding the precise indications for intervention in recurrent carotid artery stenosis.
Background:
There is significant variation in the indications for intervention in patients with recurrent carotid artery stenosis. The aim of the present study was to describe these indications in a contemporary cohort of patients.
Methods:
This was a systematic review of all peer-reviewed studies reporting on the indications for carotid intervention in patients with recurrent stenosis after carotid endarterectomy (CEA) or carotid artery stenting (CAS) that were published between 1990 and 2012.
Results:
There were 50 studies reporting on a total of 3524 patients undergoing a carotid procedure; of these, 3478 underwent CEA as the initial intervention. Reintervention was by CEA in 2403 patients and by CAS in 1121. Only 54·7 per cent of the patients were treated for any symptoms and, importantly, just 444 (23·1 per cent of 1926 symptomatic patients) underwent intervention for documented ipsilateral symptoms. None of the studies reported whether the patients were evaluated for other sources of emboli. The remaining 45·3 per cent of patients had asymptomatic restenosis and in the majority of the studies were treated when the degree of stenosis exceeded 80 per cent. The time to repeat intervention was significantly longer in patients with recurrent atherosclerosis, in asymptomatic patients and in patients undergoing CEA.
Conclusion:
The reported criteria for retreatment of carotid stenosis were not rigorous and there is still significant ambiguity surrounding the indications for intervention.
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