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A huge coronary artery aneurysm in osteogenesis imperfecta: a case report

Shokoufeh Hajsadeghi1, Scott Reza Jafarian Kerman, Hamidreza Pouraliakbar

  • 1Department of Cardiology, Rasoul-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Acta Medica Iranica
|January 8, 2013
PubMed

Insights

Osteogenesis imperfecta, a connective tissue disorder, can impact cardiac health. This study highlights coronary artery aneurysm as a rare but serious complication, observed in a patient with myocardial infarction.

Area of Science:

  • Genetics and Molecular Biology
  • Cardiology
  • Connective Tissue Diseases

Background:

  • Osteogenesis imperfecta (OI) is an inherited disorder affecting type I collagen, crucial for connective tissues.
  • While cardiac issues like aortic dilatation are known in OI, coronary artery complications are exceptionally rare.
  • Understanding OI's full spectrum of complications is vital for patient management.

Observation:

  • A rare case of coronary artery aneurysm was identified in a 19-year-old female with Osteogenesis imperfecta.
  • The patient presented with acute myocardial infarction and hypotension, indicative of severe cardiac compromise.
  • This presentation underscores the potential for unusual cardiovascular manifestations in OI.

Findings:

  • Coronary artery aneurysm represents a previously underreported cardiac complication of Osteogenesis imperfecta.
  • The case demonstrates a link between OI, collagen defects, and potentially compromised coronary artery integrity.
  • Early recognition of such rare cardiac events is critical for timely intervention.

Implications:

  • This finding expands the known cardiac manifestations of Osteogenesis imperfecta.
  • It suggests a need for heightened cardiovascular surveillance in OI patients, particularly for rarer complications.
  • Further research into the mechanisms linking OI and coronary artery disease is warranted.

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