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Related Experiment Video

Updated: May 15, 2026

Dissection of the Endolymphatic Sac from Mice

Dissection of the Endolymphatic Sac from Mice

Published on: March 29, 2021

Experimental hyperactivity of the endolymphatic sac.

Morten Friis¹, Allan Randrup Thomsen, Steen Seier Poulsen

¹Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet, and Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark. morten_friis@hotmail.com

Audiology & Neuro-Otology

|January 9, 2013

Summary

Injury to the endolymphatic sac may cause Ménière

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Area of Science:

Otolaryngology
Inner ear physiology
Immunology

Background:

Ménière's disease is an inner ear disorder.
Endolymphatic sac injury is implicated in its pathogenesis.
The specific mechanisms are not fully understood.

Purpose of the Study:

To investigate the effects of endolymphatic sac stimulation in rats.
To identify potential autoantigens or factors involved in Ménière's disease pathogenesis.
To examine ultrastructural changes in the endolymphatic sac.

Main Methods:

Isoimmunization of Lewis rats with endolymphatic sac extract.
Administration of complete Freund's adjuvant.
Transmission electron microscopy and immunohistochemistry.

Main Results:

All immunized rats showed endolymphatic sac hyperactivity.
Hyperactivity correlated with the number of injections.
Ultrastructural changes, including ribosome-rich cell alterations, were observed.

Conclusions:

The endolymphatic sac contains factors that induce hyperactivity.
These findings suggest an autoimmune component or trophic factor in Ménière's disease.
Specific cellular changes mirror those seen in human Ménière's disease.