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Published on: November 30, 2022
Approach to vicinal t-Boc-amino dibromides via catalytic aminobromination of nitrostyrenes without using
Hao Sun1, Jianlin Han, Padmanabha V Kattamuri
1School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.
Abstract:
A 1.0 mol % amount of K(3)PO(4)·3H(2)O was found to catalyze aminohalogenation reaction of nitrostyrenes with N,N-dibromo-tert-butylcarbamate (t-Boc-NBr(2)) in a dichloroethane system. Good to excellent yields and complete regioselectivity have been achieved by taking advantage of the GAP workup without using traditional purification techniques such as column chromatography and recrystallization. Anew mechanism is proposed involving radical and ionic catalytic cycles and an intramolecular migration.
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