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Monitoring of intraocular pressure and its correlation with systemic parameters before and after hemodialysis
Reza Afshar1, Hassan Ghasemi, Hoda Shabpiray
1Division of Nephrology and Nephrology Research Center, Shahed University, Tehran, Iran.
Insights
Hemodialysis can lower intraocular pressure (IOP) in patients with end-stage renal disease. Increased blood glucose levels during hemodialysis are linked to decreased IOP, particularly in non-diabetic individuals.
Area of Science:
- Ophthalmology
- Nephrology
- Internal Medicine
Background:
- End-stage renal disease (ESRD) and hemodialysis (HD) are known to influence intraocular pressure (IOP).
- Understanding these effects is crucial for managing ocular health in ESRD patients.
Purpose of the Study:
- To evaluate the acute effects of a single hemodialysis session on intraocular pressure.
- To investigate the relationship between metabolic changes during hemodialysis and IOP variations.
Main Methods:
- A prospective study involving 65 hemodialysis patients (130 eyes) without glaucoma.
- Intraocular pressure (IOP) was measured before and hourly during hemodialysis.
- Demographic data and various clinical parameters, including blood glucose, were recorded.
Main Results:
- Mean IOP decreased significantly during hemodialysis compared to predialysis levels (P = .02).
- IOP showed a significant reduction within the first two hours of hemodialysis (P < .001).
- A significant inverse relationship was observed between IOP and blood glucose changes post-hemodialysis (r = -0.180, P = .040).
Conclusions:
- Hemodialysis can lead to a significant decrease in intraocular pressure.
- Elevated blood glucose levels are associated with reduced IOP in hemodialysis patients without glaucoma.
- Metabolic changes other than blood glucose do not appear to significantly impact IOP during hemodialysis.
Introduction:
End-stage renal disease and hemodialysis affect intraocular pressure (IOP). This study aimed to evaluate the effects of a one session of hemodialysis on IOP.
Materials And Methods:
In this study, the IOP of 130 eyes of 65 hemodialysis patients (38 men and 27 women) was measured before and every 1 hour after the initiation of hemodialysis therapy. Patients with any glaucomatous conditions were excluded. Demographic information including age, gender, underling systemic or ocular diseases, hemodialysis duration and frequency, KT/V, and levels of blood pressure, body weight, blood urea, serum sodium, serum potassium, blood glucose before and after hemodialysis were recorded.
Results:
The mean age of the patients was 60.3 +/- 16.7 years. The mean predialysis and postdialysis IOPs were 13.50 +/- 4.09 mm Hg and 12.73 +/- 4.07 mm Hg, respectively (P = .02). The mean IOP at the first and second hours (12.32 mm Hg and 11.83 mm Hg, respectively) of hemodialysis were significantly lower than the mean predialysis IOP (P < .001 for each). In nondiabetics, the mean IOP significantly decreased after hemodialysis. The mean predialysis and postdialysis blood glucose levels were significantly different between diabetics and nondiabetics, but were not significant in each group of diabetics and nondiabetics. There was a significant inverse relationship between IOP and blood glucose changes after hemodialysis (r = -0.180, P = .040).
Conclusions:
Increased blood glucose levels significantly decreases IOP in hemodialysis patients without glaucomatous features. Changes in other metabolic parameters do not affect IOP during hemodialysis.
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