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From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
Published on: March 24, 2018
Amphiphilic behavior of two phosphonium based ionic liquids.
Indrajyoti Mukherjee1, Suvasree Mukherjee, Bappaditya Naskar
1Centre for Surface Science, Department of Chemistry, Jadavpur University, Kolkata, India.
Journal of Colloid and Interface Science
|January 16, 2013
Summary
Two phosphonium-based ionic liquids (ILs) exhibit distinct solution and surface behaviors. IL-1 shows anti-cancer activity, while both ILs form stable microemulsions, offering potential in various applications.
Area of Science:
- Materials Science
- Physical Chemistry
- Biochemistry
Background:
- Ionic liquids (ILs) are versatile materials with tunable properties.
- Understanding their solution and surface behavior is crucial for application development.
- Phosphonium-based ILs offer unique characteristics compared to imidazolium counterparts.
Purpose of the Study:
- To investigate the solution and surface chemical behavior of two phosphonium-based ionic liquids: triisobutyl (methyl) phosphonium tosylate (IL-1) and trihexyl (tetradecyl) phosphonium bis 2,4,4-(trimethylpentyl)phosphinate (IL-2).
- To explore their potential in forming microemulsions and their anti-cancer activity.
- To characterize the resulting microemulsion systems and assess their thermal stability.
Main Methods:
- Surface activity and solubility measurements.
- Micellization studies with various surfactants.
- Langmuir monolayer formation at the air/water interface.
- Microemulsion formation and characterization using pseudoternary phase diagrams.
- Dynamic Light Scattering (DLS) for droplet size and polydispersity.
- Thermodynamic analysis of microemulsion formation.
- In vitro anti-cancer activity testing against Sarcoma-180 cell lines.
Main Results:
- IL-1 is polar, water-soluble, and surface-active, while IL-2 is weakly polar, less soluble, and more surface-active.
- IL-1 influences surfactant micellization more than conventional electrolytes; IL-2 forms micelles and mixed micelles.
- Both ILs facilitate the formation of stable microemulsions with oil (isopropylmyristate) and co-surfactants, exhibiting large monophasic zones.
- DLS confirmed nano-droplet formation with varying dimensions and polydispersity.
- IL-1 demonstrated proficient anti-cancer activity, while IL-2 showed moderate activity against Sarcoma-180 cells.
Conclusions:
- The distinct physicochemical properties of IL-1 and IL-2 enable diverse applications, from microemulsion formulation to potential therapeutics.
- Phosphonium-based ILs offer unique advantages in micellar and interfacial phenomena.
- The studied ILs present promising candidates for advanced material applications and possess significant anti-cancer potential.
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