Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Supercritical Fluid Chromatography01:18

Supercritical Fluid Chromatography

Supercritical fluid chromatography (SFC) provides a beneficial substitute for gas chromatography (GC) and liquid chromatography (LC) for certain samples because it merges the top attributes of both techniques. SFC allows the separation and analysis of compounds that GC or LC does not easily manage. These compounds are traditionally nonvolatile or thermally unstable, making GC unsuitable and lacking functional groups required for HPLC analysis.
SFC utilizes a supercritical fluid mobile phase,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrochemical Switch-On of Nonlinear Optical Response in a Nitro-Functionalized Arylimido-Polyoxometalate.

Angewandte Chemie (International ed. in English)·2026
Same author

Label-Free Visualization of the Antifungal Polyene Drug, Nystatin, in Biological Membranes Using Raman Microscopy.

Analytical chemistry·2026
Same author

Visualization of a Bruton's Tyrosine Kinase Inhibitor Using Fluorescence and Raman Microscopy.

Analytical chemistry·2026
Same author

Development of a surface enhanced Raman scattering lateral flow immunoassay with prolonged reproducibility and stability over time.

The Analyst·2026
Same author

Correction to "Detection of Inflammation in Vivo by Surface-Enhanced Raman Scattering Provides Higher Sensitivity Than Conventional Fluorescence Imaging".

Analytical chemistry·2026
Same author

A Chemical Probe for Prostate-Specific Membrane Antigen for Real-Time Raman Imaging of Prostate Cancer Cells.

ACS sensors·2026
Same journal

Stability constants of lanthanide-nitrate complexes in aqueous solutions: a theoretical study.

Physical chemistry chemical physics : PCCP·2026
Same journal

Lead-free Cs<sub>3</sub>MnCl<sub>5</sub> and CsMnCl<sub>3</sub> crystals: rapid on-chip crystallization, phase transition and fluorescence sensing applications.

Physical chemistry chemical physics : PCCP·2026
Same journal

F-Interstitial passivation preserves host-like optoelectronic properties in <sup>229</sup>Th:YLF nuclear-clock platforms.

Physical chemistry chemical physics : PCCP·2026
Same journal

Structural trends of tryptophan dimer: hydrogen bonding <i>versus</i> π-stacking from an energy decomposition analysis perspective.

Physical chemistry chemical physics : PCCP·2026
Same journal

Achieving high thermoelectric performance in Sb<sub>2</sub>Se<sub>3</sub>-alloyed GeTe through synergistic optimization of electrical and thermal transport.

Physical chemistry chemical physics : PCCP·2026
Same journal

Ultraviolet perfect absorption leveraging bound states in the continuum in an Al/SiO<sub>2</sub> hybrid system.

Physical chemistry chemical physics : PCCP·2026
See all related articles

Related Experiment Video

Updated: May 15, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Recent developments and future directions in SERS for bioanalysis.

Mhairi M Harper1, Kristy S McKeating, Karen Faulds

  • 1Centre for Molecular Nanometrology, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK.

Physical Chemistry Chemical Physics : PCCP
|January 16, 2013
PubMed
Summary
This summary is machine-generated.

Surface enhanced Raman scattering (SERS) offers sensitive detection of biomolecules like DNA and proteins. This technique shows promise for advancing pre-clinical diagnostics and personalized medicine from the lab to clinical settings.

More Related Videos

Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes
06:19

Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes

Published on: June 9, 2023

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants
08:13

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants

Published on: February 19, 2016

Related Experiment Videos

Last Updated: May 15, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes
06:19

Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes

Published on: June 9, 2023

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants
08:13

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants

Published on: February 19, 2016

Area of Science:

  • Biophotonics
  • Spectroscopy
  • Nanotechnology

Background:

  • Sensitive biomolecule detection is vital for early disease diagnosis and tailored treatments.
  • Surface enhanced Raman scattering (SERS) provides highly sensitive and multiplexed analysis capabilities.
  • Current diagnostic methods require improvement in sensitivity and specificity.

Purpose of the Study:

  • To review the successful applications of SERS in detecting biomolecules, including DNA and proteins.
  • To highlight the potential of in vivo SERS analysis.
  • To discuss the future development of SERS for clinical translation.

Main Methods:

  • Literature review of SERS applications in biomolecule detection.
  • Analysis of studies utilizing in vivo SERS.
  • Discussion of challenges and requirements for clinical implementation.

Main Results:

  • SERS has demonstrated high sensitivity in detecting DNA and proteins.
  • Successful in vivo applications of SERS have been reported.
  • Significant progress has been made in adapting SERS for biological samples.

Conclusions:

  • SERS is a powerful tool for sensitive biomolecule detection with potential in diagnostics.
  • Further research and development are needed to bridge the gap between laboratory findings and clinical application.
  • The translation of SERS to clinical settings will enhance pre-clinical disease diagnosis and patient-specific treatment strategies.