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Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Functional interplay between the cell cycle and cell phenotypes.

Wei-Chiang Chen1, Pei-Hsun Wu, Jude M Phillip

  • 1Johns Hopkins Physical Sciences-Oncology Center, The Johns Hopkins University, Baltimore, Maryland 21218, USA.

Integrative Biology : Quantitative Biosciences From Nano to Macro
|January 16, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a novel microscopy method to simultaneously measure cell cycle phase and cell properties in adherent cells. This high-throughput assay reveals complex interactions between cell cycle regulators and structural proteins.

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Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
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Related Experiment Videos

Last Updated: May 15, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Published on: June 6, 2017

Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
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Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

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Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

Area of Science:

  • Cell Biology
  • Microscopy
  • High-throughput screening

Background:

  • Flow cytometry is standard for cell cycle analysis but limits simultaneous phenotype measurement.
  • Existing methods cannot assess cell properties and cell cycle phase in the same environment.

Purpose of the Study:

  • To develop and validate a microscopy system for simultaneous cell cycle and phenotype analysis.
  • To enable high-throughput, single-cell resolution studies of cell cycle-phenotype interplay.

Main Methods:

  • Development of a quantitative microscopy system for adherent cells.
  • Simultaneous measurement of cell-cycle phase and cell properties.
  • Perturbation of cell cycle regulators and nuclear structural proteins.

Main Results:

  • Demonstrated that population-averaged cell phenotypes are a linear combination of cell-cycle fractions and phase-dependent phenotypes.
  • Revealed significant interference between cell cycle regulators and structural proteins.
  • Established a high-throughput method for simultaneous cell cycle and phenotype measurement.

Conclusions:

  • The developed microscopy system allows simultaneous, high-throughput analysis of cell cycle and phenotypes.
  • Cell cycle regulators and structural proteins exhibit complex functional interactions.
  • This method provides new insights into the interplay between cell cycle dynamics and cellular phenotypes.