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2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum
Published on: December 8, 2023
Diterpenoid alkaloids from Aconitum kirinense.
Sai-Yang Zhang1, Ying Jiang, Yue-Feng Bi
1School of Pharmaceutical Sciences & New Drug Research and Development Center, Zhengzhou University, Zhengzhou 450001, China.
Journal of Asian Natural Products Research
|January 18, 2013
Summary
Researchers discovered kirinenine A, a novel C(18)-diterpenoid alkaloid, from Aconitum kirinense roots. This study details the isolation and structural characterization of this new compound and eight known alkaloids.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Medicinal Chemistry
Background:
- Aconitum species are known sources of bioactive alkaloids.
- Diterpenoid alkaloids possess diverse pharmacological properties.
- The chemical constituents of Aconitum kirinense are not fully elucidated.
Purpose of the Study:
- To isolate and identify novel and known diterpenoid alkaloids from Aconitum kirinense roots.
- To elucidate the structure of a new C(18)-diterpenoid alkaloid.
Main Methods:
- Extraction and isolation of alkaloids from Aconitum kirinense root.
- Structure elucidation using Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS).
- X-ray crystallographic diffraction for definitive structural confirmation of the new compound.
Main Results:
- Isolation of a new C(18)-diterpenoid alkaloid, named kirinenine A (1).
- Identification of eight known diterpenoid alkaloids.
- Comprehensive structural characterization of all isolated compounds.
- Confirmation that all isolated compounds are reported from this plant for the first time.
Conclusions:
- Kirinenine A is a novel diterpenoid alkaloid isolated from Aconitum kirinense.
- The study expands the known chemical diversity of Aconitum alkaloids.
- This research provides a foundation for further investigation into the biological activities of these compounds.
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