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Related Concept Videos

Riboswitches01:56

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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  1. Home
  3. A Decade Of Riboswitches.
  1. Home
  3. A Decade Of Riboswitches.

Related Experiment Video

Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

A decade of riboswitches.

Alexander Serganov1, Evgeny Nudler

  • 1Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. alexander.serganov@nyumc.org

Cell
|January 22, 2013

View abstract on PubMed

Summary
This summary is machine-generated.

Riboswitches are RNA sensors that regulate gene expression by binding small molecules. These natural sensors have broad applications in medicine and synthetic biology.

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Related Experiment Videos

Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

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Published on: August 7, 2021

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data
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Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Riboswitches are RNA molecules that sense and bind small metabolites.
  • First discovered in bacteria, they regulate gene expression in all domains of life.
  • Their regulatory roles extend to transcription, translation, splicing, and RNA stability.

Purpose of the Study:

  • To review the fundamental principles of riboswitch function.
  • To highlight the diverse roles and mechanisms of riboswitches.
  • To discuss the implications of riboswitch research.

Main Methods:

  • Biochemical studies
  • Structural analyses
  • Genetic investigations

Main Results:

  • Riboswitches bind various small molecules and ions.
  • They control gene expression through diverse mechanisms.
  • Their function is conserved across bacteria, archaea, and eukaryotes.

Conclusions:

  • Riboswitches are versatile genetic regulatory elements.
  • Understanding riboswitches has implications for antibiotic development.
  • Riboswitches can be engineered for molecular sensing and synthetic biology circuits.