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Updated: May 15, 2026
14:40
Expression Analysis of Mammalian Linker-histone Subtypes
Published on: March 19, 2012
High HIF-1α expression genotypes in oral lichen planus
Carlos Alberto de Carvalho Fraga1, Lucas Rodrigues Alves, Luciano Marques-Silva
1Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
Clinical Oral Investigations
|January 22, 2013
Summary
Specific gene variations in hypoxia-inducible factor-1 (HIF-1)α are linked to an increased risk of developing oral lichen planus (OLP). These HIF-1α polymorphisms may influence the progression and chronicity of OLP lesions.
Area of Science:
- Genetics and Molecular Biology
- Oral Pathology
- Immunology
Background:
- Oral lichen planus (OLP) is a chronic inflammatory condition affecting oral mucosa.
- The role of hypoxia-inducible factor-1 (HIF-1)α in OLP pathogenesis is not fully understood.
- Genetic variations in HIF-1α may influence susceptibility and disease progression.
Purpose of the Study:
- To investigate the association between C1772T and G1790A polymorphisms of the HIF-1α gene and the risk of OLP.
- To explore the potential role of HIF-1α in the development and chronicity of OLP.
Main Methods:
- Restriction fragment length polymorphism (RFLP) analysis was employed.
- Genotyping of HIF-1α C1772T and G1790A polymorphisms was performed.
- Case-control study involving 32 OLP patients and 88 healthy controls.
Main Results:
- The CC, TT, GA, and AA genotypes of HIF-1α were found at higher frequencies in OLP patients.
- Significant associations between OLP risk and C and A, as well as T and A haplotypes of HIF-1α were observed.
- Allelic imbalance patterns differed between normal samples and chronic OLP lesions.
Conclusions:
- C1772T and G1790A polymorphisms in the HIF-1α gene are associated with an increased risk of OLP.
- HIF-1α likely plays a role in the chronicity of oral mucosal lesions in OLP.
- Further research into the HIF-1α pathway is warranted for developing novel OLP therapeutic strategies.
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