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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...

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Related Experiment Video

Updated: May 15, 2026

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System
08:24

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System

Published on: February 28, 2017

Amniotic fluid stem cells and fetal cell microchimerism.

Margit Rosner1, Markus Hengstschläger

  • 1Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090 Vienna, Austria.

Trends in Molecular Medicine
|January 23, 2013
PubMed
Summary
This summary is machine-generated.

Fetal cells circulate in pregnant women and show stem cell properties. Researchers propose these reparative cells and amniotic fluid stem cells may originate from a common source.

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Last Updated: May 15, 2026

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Area of Science:

  • Reproductive biology
  • Stem cell research
  • Maternal-fetal medicine

Background:

  • Fetal cells and cell-free fetal DNA are present in maternal circulation.
  • These circulating fetal cells possess stem cell properties and can differentiate at sites of maternal tissue injury.
  • The origin of these naturally occurring, reparative fetal cells remains unidentified.

Purpose of the Study:

  • To explore the potential origin of circulating fetal cells found in pregnant women.
  • To investigate the relationship between circulating fetal cells and pluripotent cells in amniotic fluid.
  • To hypothesize a common origin for these distinct fetal cell populations.

Main Methods:

  • Review of existing literature on fetal cell circulation and stem cell properties.
  • Analysis of the biological context of fetal cell presence during pregnancy.
  • Comparative discussion of circulating fetal cells and amniotic fluid-derived stem cells.

Main Results:

  • Circulating fetal cells exhibit stem cell characteristics and potential reparative functions.
  • Pluripotent fetal stem cells are found mobilized in the amniotic fluid during pregnancy.
  • The study posits a shared origin for circulating fetal cells and amniotic fluid stem cells.

Conclusions:

  • Circulating fetal cells in maternal blood likely originate from a common source with amniotic fluid stem cells.
  • Further research is needed to elucidate the in vivo significance and precise origin of these fetal cells.
  • Understanding the origin of these cells could have implications for regenerative medicine and prenatal diagnostics.