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Genetic associations with neonatal thyroid-stimulating hormone levels
Farah Y Alul1, Oleg A Shchelochkov, Stanton L Berberich
1Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
Pediatric Research
|January 25, 2013
Summary
This study identified two genetic markers associated with neonatal thyroid-stimulating hormone (TSH) levels, replicating adult findings. These genetic variations may predict future thyroid conditions in newborns.
Area of Science:
- Endocrinology
- Genetics
- Neonatal Medicine
Background:
- Thyroid hormone imbalances cause diverse neonatal and adult health issues.
- Previous genetic studies focused on adult thyroid hormones, leaving neonatal associations unexplored.
Purpose of the Study:
- To investigate genetic associations with neonatal thyroid-stimulating hormone (TSH) levels.
- To identify potential genetic predictors for thyroid disorders in newborns.
Main Methods:
- Genotyped 1642 neonates (term and preterm) for 45 single-nucleotide polymorphisms (SNPs).
- Analyzed TSH values from the Iowa Neonatal Metabolic Screening Program.
- Utilized ANOVA to determine genetic associations with TSH concentrations.
Main Results:
- Identified significant associations between TSH levels and two SNPs: rs4704397 in PDE8B and rs965513 near FOXE1.
- Both identified SNPs met statistical significance after multiple testing correction.
- Six additional SNPs showed marginal significance (P < 0.05).
Conclusions:
- This study is the first to demonstrate genetic associations with neonatal TSH levels, confirming findings in adults.
- Identified SNPs may serve as early indicators for adult diseases linked to thyroid hormone levels.
- Provides enhanced understanding of neonatal thyroid profiles and potential disorder risks.
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