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iPS Cell Differentiation

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APLP2 regulates neuronal stem cell differentiation during cortical development.

S Ali M Shariati1, Pierre Lau, Bassem A Hassan

  • 1KU Leuven, Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, 3000 Leuven, Belgium.

Journal of Cell Science
|January 25, 2013
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Summary
This summary is machine-generated.

Amyloid precursor like protein 2 (APLP2) is crucial for neuronal differentiation. Silencing APLP2 in developing brains delays progenitor cell cycle exit, impacting neurogenesis.

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Published on: April 12, 2015

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Amyloid precursor protein (APP) and its paralogues APLP1 and APLP2 are expressed during brain development.
  • Previous studies on their roles in embryonic brain development yielded contradictory findings.

Purpose of the Study:

  • To elucidate the specific role of APLP2 in neurogenesis.
  • To address conflicting conclusions from prior genetic knockout and shRNA studies.

Main Methods:

  • In vivo silencing of APLP2 in a mouse model lacking APP and APLP1.
  • Analysis of cortical progenitor cell cycle exit and neuronal migration.

Main Results:

  • Cortical progenitors remained undifferentiated longer with increased mitotic activity when APLP2 was silenced.
  • Neuron-specific APLP2 downregulation did not affect the migration speed or position of excitatory cortical neurons.

Conclusions:

  • APLP2 is essential for the timely cell cycle exit of neuronal progenitors.
  • APLP2 plays a distinct role in preparing cortical progenitors for neuronal differentiation.