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Updated: May 14, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Prostate cancer brachytherapy: guidelines overview.

Piotr Wojcieszek1, Brygida Białas

  • 1Brachytherapy Department, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice, Poland.

Journal of Contemporary Brachytherapy
|January 26, 2013
PubMed
Summary

This review examines European and North American guidelines for prostate cancer treatment, highlighting brachytherapy as a top curative option. It focuses on HDR and LDR brachytherapy recommendations for early-stage disease management.

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MUlticentre REtrospective comparison of definitive EBRT with or without HDR BRAchytherapy boost in patients with locally-advanced prostate cancer and regional lymph NOde metastases (MUREBRANO) - A propensity score matched analysis.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025

Area of Science:

  • Oncology
  • Radiation Oncology
  • Urology

Background:

  • Prostate cancer is frequently diagnosed in early stages due to widespread PSA testing.
  • Managing early-stage prostate cancer presents challenges in clinical oncology.
  • Treatment options include surgery, radiotherapy, and active surveillance, necessitating careful selection.

Purpose of the Study:

  • To overview current European and North American treatment guidelines for prostate cancer.
  • To specifically focus on the role of brachytherapy, including HDR and LDR modalities.
  • To inform treatment decisions for early-stage prostate cancer based on expert recommendations.

Main Methods:

  • Review of guidelines from major oncology organizations: NCCN, ASTRO, ABS, EAU, and GEC-ESTRO.
Keywords:
dose constrainsdose prescriptionfollow-uppermanent seedstemporary implant

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  • Comparative analysis of recommendations for prostate cancer management.
  • Specific focus on brachytherapy (HDR and LDR) within these guidelines.

    • Main Results:

    • Brachytherapy is recognized as a superior curative option for prostate cancer in recent studies.
    • Guidelines from European and North American bodies offer varying but consistent support for brachytherapy.
    • HDR and LDR brachytherapy are detailed as key treatment modalities within the reviewed recommendations.

    Conclusions:

    • Brachytherapy represents a highly effective treatment for early-stage prostate cancer.
    • Adherence to established guidelines ensures optimal patient management.
    • Further research and guideline updates are crucial for advancing prostate cancer care.