Biochemistry and structure of phosphoinositide phosphatases
Young Jun Kim1, Nusrat Jahan, Young Yil Bahk
1Department of Biotechnology, Konkuk University, Chungju, Korea.
Abstract:
Phosphoinositides are the phosphorylated derivatives of phosphatidylinositol, and play a very significant role in a diverse range of signaling processes in eukaryotic cells. A number of phosphoinositide-metabolizing enzymes, including phosphoinositide-kinases and phosphatases are involved in the synthesis and degradation of these phospholipids. Recently, the function of various phosphatases in the phosphatidylinositol signaling pathway has been of great interest. In the present review we summarize the structural insights and biochemistry of various phosphatases in regulating phosphoinositide metabolism.
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