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Updated: May 14, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
An evidence-based patient-centered method makes the biopsychosocial model scientific
Robert C Smith1, Auguste H Fortin, Francesca Dwamena
1Departments of Medicine and Psychiatry, Michigan State University College of Human Medicine, East Lansing, MI, USA. robert.smith@ht.msu.edu
Objective:
To review the scientific status of the biopsychosocial (BPS) model and to propose a way to improve it.
Discussion:
Engel's BPS model added patients' psychological and social health concerns to the highly successful biomedical model. He proposed that the BPS model could make medicine more scientific, but its use in education, clinical care, and, especially, research remains minimal. Many aver correctly that the present model cannot be defined in a consistent way for the individual patient, making it untestable and non-scientific. This stems from not obtaining relevant BPS data systematically, where one interviewer obtains the same information another would. Recent research by two of the authors has produced similar patient-centered interviewing methods that are repeatable and elicit just the relevant patient information needed to define the model at each visit. We propose that the field adopt these evidence-based methods as the standard for identifying the BPS model.
Conclusion:
Identifying a scientific BPS model in each patient with an agreed-upon, evidence-based patient-centered interviewing method can produce a quantum leap ahead in both research and teaching.
Practice Implications:
A scientific BPS model can give us more confidence in being humanistic. In research, we can conduct more rigorous studies to inform better practices.
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