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T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease I: Introduction

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Coronary Artery Disease III: Clinical Manifestations

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Related Experiment Video

Updated: May 14, 2026

Intracellular Staining and Flow Cytometry to Identify Lymphocyte Subsets within Murine Aorta, Kidney and Lymph Nodes in a Model of Hypertension

Intracellular Staining and Flow Cytometry to Identify Lymphocyte Subsets within Murine Aorta, Kidney and Lymph Nodes in a Model of Hypertension

Published on: January 28, 2017

Association between CD8+ T-cell subsets and cardiovascular disease.

D Kolbus¹, I Ljungcrantz, L Andersson

¹Department of Clinical Sciences Malmö, Lund University, Sweden.

Journal of Internal Medicine

|January 30, 2013

Summary

This summary is machine-generated.

High CD8(+) T cells are linked to increased cardiovascular events and insulin resistance. Specific CD8(+) T-cell subsets correlate with carotid stenosis severity, indicating their role in atherosclerosis.

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Intracellular Staining and Flow Cytometry to Identify Lymphocyte Subsets within Murine Aorta, Kidney and Lymph Nodes in a Model of Hypertension

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Area of Science:

Immunology
Cardiovascular Medicine
Atherosclerosis Research

Background:

Experimental studies suggest immune system involvement in atherosclerosis.
Clinical significance of specific immune cells in cardiovascular disease is not well understood.

Purpose of the Study:

Investigate the association between CD8(+) T cells and carotid disease.
Examine the link between CD8(+) T cells and cardiovascular disease events.

Main Methods:

Analyzed 700 subjects from the Malmö Diet and Cancer Study.
Used flow cytometry to assess CD8(+) T-cell populations in stored peripheral blood mononuclear cells.
Assessed carotid intima-media thickness, stenosis via ultrasonography, and monitored clinical events.

Main Results:

Higher CD8(+) T-cell fractions correlated with decreased cytokine release, insulin resistance, and increased coronary events.
Significant associations found between CD8(+) CD25(+) T cells and carotid stenosis degree.
CD8(+) CD56(-) IFN-γ(+) T-cell fraction linked to carotid stenosis, even after risk factor adjustment.

Conclusions:

Provides prospective clinical evidence for CD8(+) T cells in cardiovascular disease.
Suggests distinct CD8(+) T-cell subsets possess varying pathological roles in atherosclerosis.