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Updated: May 14, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
Recurrent, delayed hemorrhage associated with edoxaban after deep brain stimulation lead placement
Walavan Sivakumar1, Sarah T Garber, Lauren E Schrock
1Department of Neurosurgery, Clinical Neurosciences Center, The University of Utah, Salt Lake City, Utah, UT 84132, USA.
Abstract:
Factor-Xa inhibitors like edoxaban have been shown to have comparable or superior rates of stroke and systemic embolization prevention to warfarin while exhibiting lower clinically significant bleeding rates. The authors report a case of a man who presented with delayed, recurrent intracranial hemorrhage months after successful deep brain stimulator placement for Parkinson disease while on edoxaban for atrial fibrillation. Further reports on the use of novel anticoagulants after intracranial surgery are acutely needed to help assess the true relative risk they pose.
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