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Injectable macroporous microparticles for soft tissue augmentation.

Abigail A Corrin1, Matthew Ngai, Christopher M Walthers

  • 1Bioengineering Department, University of California Los Angeles. Los Angeles, CA 90095, USA. acorrin@ucla.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|February 1, 2013
PubMed
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Researchers created macroporous polymeric microparticles using particulate leaching and gas foaming. These PCL microparticles feature interconnected pores, potentially enhancing cell and tissue ingrowth for biomedical applications.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Macroporous materials are crucial for tissue regeneration and drug delivery.
  • Polymeric microparticles offer versatile platforms for biomedical applications.
  • Existing fabrication methods have limitations in pore control and scalability.

Purpose of the Study:

  • To develop a novel method for fabricating macroporous polymeric microparticles.
  • To control pore size and interconnectivity for enhanced biological integration.
  • To create a versatile template for tailored material and biological specifications.

Main Methods:

  • Fabrication of macroporous poly (ε-caprolactone) (PCL) microparticles.
  • Utilized a combination of particulate leaching and gas foaming techniques.

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  • Controlled ammonium bicarbonate particle concentration and microemulsion spin speed.

    • Main Results:

    • Successfully fabricated macroporous microparticles with interconnected pores ranging from 10-50 µm.
    • Demonstrated tunability of pore structure by adjusting fabrication parameters.
    • Pore characteristics suggest potential for promoting cell and tissue ingrowth in vivo.

    Conclusions:

    • A novel and adaptable technique for creating macroporous polymeric microparticles was established.
    • The fabricated PCL microparticles show promise for subcutaneous implantation and promoting tissue regeneration.
    • This method provides a versatile platform for developing advanced biomaterials.