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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Related Experiment Video

Updated: May 14, 2026

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
09:10

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

Mesenchymal stem cell-educated macrophages.

Elke Eggenhofer1, Martin J Hoogduijn

  • 1Department of Surgery, University Medical Center of Regensburg, Franz-Josef-Strauss Allee 11, Regensburg, Germany. elke.eggenhofer@ukr.de.

Transplantation Research
|February 2, 2013
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSC) can suppress immune responses by educating macrophages. This review explores MSC-macrophage interactions and the clinical potential of MSC-educated macrophages for immune modulation.

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Production and Characterization of Human Macrophages from Pluripotent Stem Cells
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Production and Characterization of Human Macrophages from Pluripotent Stem Cells

Published on: April 16, 2020

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Last Updated: May 14, 2026

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
09:10

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

Production and Characterization of Human Macrophages from Pluripotent Stem Cells
08:05

Production and Characterization of Human Macrophages from Pluripotent Stem Cells

Published on: April 16, 2020

Area of Science:

  • Immunology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Mesenchymal stem cells (MSC) possess immunosuppressive properties.
  • MSC-induced immunomodulatory macrophages are a key mechanism of MSC function.
  • Local MSC-macrophage interactions in tissues can influence immune regulation.

Purpose of the Study:

  • To review the interaction between MSC and macrophages.
  • To discuss the induction and properties of MSC-educated macrophages.
  • To explore the clinical applications of MSC-macrophage interactions in cell therapy.

Main Methods:

  • Literature review of studies on MSC-macrophage interactions.
  • Analysis of mechanisms underlying MSC-mediated macrophage education.
  • Discussion of the positioning of MSC-educated macrophages within the immune landscape.

Main Results:

  • MSC educate macrophages to acquire immunomodulatory and regulatory properties.
  • MSC-macrophage interactions represent a significant mechanism for MSC immunosuppression.
  • MSC-educated macrophages exhibit distinct characteristics compared to other immune regulatory cells.

Conclusions:

  • MSC-educated macrophages hold therapeutic potential for immune-related diseases.
  • Understanding MSC-macrophage interplay is crucial for optimizing MSC-based therapies.
  • Targeting local macrophage populations with MSC offers a promising clinical strategy.