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Possible interaction between SPPS and enalapril
1Department of Anaesthesia and Intensive Care, Palmerston North Hospital, New Zealand.
Anaesthesia and Intensive Care
|February 1, 1990
Summary
Angiotensin converting enzyme inhibitor therapy may cause hypotension during rapid infusion of stable plasma protein solution. This suggests ACE inhibitor use is a relative contraindication for rapid SPPS administration.
Area of Science:
- Anesthesiology
- Pharmacology
- Cardiovascular Medicine
Background:
- Patient received enalapril for hypertension management during surgery.
- Surgical procedure involved groin lymph node dissection under spinal and general anesthesia.
Observation:
- Rapid infusion of stable plasma protein solution (SPPS) led to significant hypotension and flushing.
- The patient was on enalapril, an angiotensin converting enzyme inhibitor.
Findings:
- A potential mechanism links SPPS infusion and ACE inhibitor pharmacology to observed adverse events.
- Hypotension and flushing suggest an interaction between SPPS and enalapril.
Implications:
- Angiotensin converting enzyme inhibitor (ACE inhibitor) therapy may be a relative contraindication for rapid SPPS infusion.
- Clinical practice should consider potential interactions between ACE inhibitors and SPPS.
- Further research is warranted to elucidate the precise mechanism of this interaction.