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XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids

Aurélie Orliac1, Domingo Gomez Pardo, Agnès Bombrun

  • 1Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.

Organic Letters
|February 7, 2013
PubMed
Summary

XtalFluor-E efficiently converts carboxylic acids and amines into amides, even for challenging substrates. This method preserves the stereochemical integrity of optically active starting materials, avoiding epimerization or racemization.

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