Nano graphene based sensor for antiarrhythmic agent quinidine in solubilized system

Area of Science:

• Electrochemistry
• Materials Science
• Analytical Chemistry

Background:

• Quinidine (QD) detection is crucial for pharmaceutical quality control.
• Existing methods for QD detection may lack sensitivity or efficiency.
• Development of advanced electrochemical sensors is needed for improved analyte quantification.

Purpose of the Study:

• To develop an ultrasensitive electrochemical sensor for quinidine detection.
• To utilize the synergistic electrocatalytic properties of nano graphene (nGN) and multiwalled carbon nanotubes (MWCNTs).
• To validate the sensor's performance in pharmaceutical formulations.

Main Methods:

• Fabrication of a modified glassy carbon electrode (GCE) with an nGN-MWCNT composite film.
• Electrochemical characterization using scanning electron microscopy (SEM) and cyclic voltammetry (CV).
• Optimization of detection conditions for quinidine quantification.

Main Results:

• The nGN-MWCNT sensor exhibited enhanced stability and catalytic activity for quinidine oxidation.
• A significant decrease in over-potential was observed compared to a bare GCE.
• Linearity was established between oxidation peak current and QD concentration (60 ng–50 μg) with a low detection limit (0.186 ng).

Conclusions:

• The developed nGN-MWCNT electrochemical sensor offers high sensitivity and stability for quinidine detection.
• The sensor is effective for analyzing quinidine in bulk drugs and pharmaceutical formulations.
• This approach provides a reliable method for quality control in the pharmaceutical industry.