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Generation of Human Alloantigen-specific T Cells from Peripheral Blood
Published on: November 21, 2014
Natural Killer T cell obsession with self-antigens
Laurent Gapin1, Dale I Godfrey, Jamie Rossjohn
1Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA. gapinl@njhealth.org
Current Opinion in Immunology
|February 7, 2013
Summary
Natural Killer T (NKT) cells recognize lipid antigens via CD1d molecules. This review explores how NKT cell autoreactivity, involving self-antigens, impacts immune responses and development.
Area of Science:
- Immunology
- Cell Biology
Background:
- Natural Killer T (NKT) cells are unique lymphocytes recognizing lipid antigens.
- These cells interact with the non-classical Major Histocompatibility Complex molecule CD1d.
- NKT cells are categorized into type I and type II based on T-cell receptor specificity.
Purpose of the Study:
- To review recent advances in understanding NKT cell autoreactivity.
- To elucidate the mechanisms of NKT T cell receptor engagement with self-antigens.
- To describe the nature of self-antigens recognized by NKT cells.
Main Methods:
- Literature review of recent research on NKT cells.
- Analysis of studies investigating NKT cell-antigen interactions.
- Synthesis of data on NKT cell development and immune regulation.
Main Results:
- Evidence suggests self-antigen recognition by NKT cells is crucial for their development.
- NKT cell autoreactivity plays a significant role in regulating diverse immune responses.
- The review details how and when NKT cell autoreactivity occurs.
Conclusions:
- Understanding NKT cell autoreactivity is key to comprehending immune system regulation.
- Further research into NKT cell-self-antigen interactions can reveal therapeutic targets.
- NKT cell recognition of self-antigens influences both cellular development and immune function.
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