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Compressed orally disintegrating tablets: excipients evolution and formulation strategies
Ali Al-khattawi1, Afzal R Mohammed
1Aston University, Aston Pharmacy School , Aston Triangle, Birmingham B4 7ET , UK. a.u.r.mohammed@aston.ac.uk
Expert Opinion on Drug Delivery
|February 8, 2013
Summary
Compressed orally disintegrating tablets (ODTs) offer a cost-effective manufacturing method for pediatric and geriatric patients. Research reviews ODT excipients and formulation strategies for enhanced disintegration and tablet strength, while noting stability concerns.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Formulation Science
Background:
- Orally disintegrating tablets (ODTs) are a novel solid oral dosage form suitable for pediatric and geriatric populations.
- Compression of excipients is a cost-effective and translatable manufacturing technology for ODTs.
Purpose of the Study:
- To review the literature on formulation development of compressed ODTs over the last two decades.
- To explore the evolution of ODT excipients, focusing on the shift from cellulose-based materials to sugars/polyols.
- To critically assess strategies for enhancing compressed ODT performance, including disintegration and mechanical strength.
Main Methods:
- Literature review of studies on compressed ODT formulation.
- Analysis of ODT excipient properties (fillers, binders, disintegrants).
- Evaluation of performance enhancement strategies and their underlying mechanisms.
Main Results:
- The review details key excipients used in ODTs since the 1990s, noting a trend towards sugar/polyol use.
- Advantages and drawbacks of various ODT fillers, binders, and disintegrants are discussed.
- Strategies for improving disintegration speed and mechanical strength in compressed ODTs are critically assessed.
Conclusions:
- Advancements in compression-based technologies are expected to lower ODT manufacturing costs.
- Potential challenges include tablet stability issues such as moisture susceptibility, pore collapse, and polymorph generation.
- Rigorous testing is essential before commercialization to address stability concerns.
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