Related Experiment Video

Updated: May 14, 2026

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
10:54

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

Published on: September 17, 2012

In the wrong place at the wrong time: does cyclin mislocalization drive oncogenic transformation?

Jonathan D Moore1

  • 1Vernalis (R&D), Granta Park, Great Abington, Cambridge CB21 6GB, UK. j.moore@horizondiscovery.com

Nature Reviews. Cancer
|February 8, 2013
PubMed
Summary

Spatial deregulation of cyclin expression and cyclin-dependent kinase (CDK) complexes is linked to cancer. Mislocalization of cyclins disrupts cell cycle control and chromosome segregation, potentially driving tumorigenesis.

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