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Idiopathic acute eosinophilic pneumonia in a 14-month-old girl
Ha Neul Park1, Bo Hyun Chung, Jung Eun Pyun
1Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea.
Insights
Idiopathic acute eosinophilic pneumonia (IAEP) is a rare pediatric condition. Early diagnosis and corticosteroid treatment led to rapid symptom resolution in a 14-month-old girl.
Area of Science:
- Pediatric Pulmonology
- Critical Care Medicine
- Pathology
Background:
- Idiopathic acute eosinophilic pneumonia (IAEP) is a rare cause of acute respiratory failure in children.
- Diagnosis requires excluding other etiologies and identifying eosinophilic infiltrates in the lungs.
Purpose of the Study:
- To report a case of IAEP in a pediatric patient.
- To highlight diagnostic criteria and treatment outcomes.
Main Methods:
- Case presentation of a 14-month-old girl with acute respiratory distress.
- Diagnostic workup included chest X-ray and lung biopsy.
- Exclusion of common causes of acute eosinophilic pneumonia.
Main Results:
- The patient presented with fever, cough, and dyspnea.
- Chest X-ray revealed multifocal consolidations and pneumothorax.
- Lung biopsy confirmed significant eosinophilic infiltrates, diagnosing IAEP.
- Symptoms resolved rapidly following corticosteroid therapy.
Conclusions:
- IAEP is a rare but treatable cause of acute respiratory failure in children.
- Prompt diagnosis and corticosteroid treatment are crucial for favorable outcomes.
- This case underscores the importance of considering IAEP in pediatric respiratory distress.
Abstract:
Idiopathic acute eosinophilic pneumonia (IAEP), characterized by acute febrile respiratory failure associated with diffuse radiographic infiltrates and pulmonary eosinophilia, is rarely reported in children. Diagnosis is based on an association of characteristic features including acute respiratory failure with fever, bilateral infiltrates on the chest X-ray, severe hypoxemia and bronchoalveolar lavage fluid >25% eosinophils or a predominant eosinophilic infiltrate in lung biopsies in the absence of any identifiable etiology. We present a 14-month-old girl who was admitted to our pediatric intensive care unit because of acute respiratory distress. She had a fever, dry cough, and progressive dyspnea for 1 day. Chest X-ray showed multifocal consolidations, increased interstitial markings, parenchymal emphysema and pneumothorax. IAEP was confirmed by marked pulmonary infiltrates of eosinophils in the lung biopsy specimen. Most known causes of acute eosinophilic pneumonia, such as exposure to causative drugs, toxins, second-hand smoking and infections were excluded. Her symptoms were resolved quickly after corticosteroid therapy.
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