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Delayed graft function after kidney transplantation: the clinical perspective.
Adnan Sharif1, Richard Borrows
1Department of Nephrology and Kidney Transplantation, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
Summary
Delayed graft function (DGF) is a major hurdle in kidney transplantation, especially with increasing use of marginal organs. This review critiques current evidence for DGF prevention and management, exploring new therapies.
Area of Science:
- Nephrology
- Transplantation Immunology
- Clinical Medicine
Background:
- Delayed graft function (DGF) presents a significant clinical challenge in kidney transplantation.
- Increasing organ demand necessitates using marginal donor kidneys, exacerbating DGF prevalence.
- Current understanding of DGF mechanisms has not translated into effective clinical therapies.
Observation:
- The use of expanded criteria and cardiac death donors is rising.
- This trend is projected to increase the incidence of DGF post-transplantation.
- Translating mechanistic insights into targeted DGF management remains elusive.
Findings:
- This article critically evaluates existing clinical evidence for targeted DGF interventions.
- It reviews emerging and experimental therapies for DGF prevention and management.
- The focus is on critiquing the available clinical evidence for targeted intervention.
Implications:
- Improved strategies are needed to manage DGF in the context of evolving donor criteria.
- Further research into novel therapeutic approaches for DGF is crucial.
- Addressing DGF is essential for optimizing kidney transplant outcomes.
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