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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: May 14, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Targeted delivery of platinum-based anticancer complexes.

Jennifer S Butler1, Peter J Sadler

  • 1Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.

Current Opinion in Chemical Biology
|February 12, 2013
PubMed
Summary

Advanced delivery systems enhance platinum-based anticancer drugs. Nanomaterials and targeted therapies improve drug transport, reduce side effects, and enable novel cancer cell killing mechanisms.

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Area of Science:

  • Nanomedicine
  • Materials Science
  • Oncology

Background:

  • Platinum-based chemotherapy is a cornerstone of cancer treatment.
  • Improving the efficacy and specificity of platinum drugs remains a critical challenge.
  • Current delivery methods can lead to systemic toxicity and limited tumor penetration.

Purpose of the Study:

  • To review recent advancements in using novel delivery and targeting systems for platinum-based anticancer drugs.
  • To explore how these systems can enhance drug transport, stability, and cancer cell specificity.
  • To highlight the potential for new mechanisms of cancer cell death induced by these modified platinum drugs.

Main Methods:

  • Functionalized carbon nanotubes (CNTs) and nanorods
  • Hollow Prussian blue (HPB) nanoparticles
  • Magnetic iron oxide and gold nanoparticles
  • Liposomes, nanogels, and polymers
  • Active targeting via conjugation to proteins and peptides (e.g., EGF, heparin, herceptin, somatostatin, TAT)
  • Spatially targeted activation of Pt(IV) prodrugs using light

Main Results:

  • These nanocarriers effectively transport and shield platinum drug centers.
  • Targeting moieties facilitate specific delivery to cancer cells.
  • Light-activated prodrugs allow for spatially controlled drug release.
  • Novel platinum species exhibit unique reactivity, leading to new cancer cell death pathways.

Conclusions:

  • Advanced nanomedicine platforms offer significant potential to improve platinum-based cancer therapy.
  • Targeted delivery and controlled activation can enhance drug efficacy and minimize side effects.
  • These innovative approaches may overcome resistance mechanisms and introduce novel therapeutic strategies in oncology.