Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tau positron emission tomography analysis methods for the quantification of tau spread in preclinical and early Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Impact of plasma pTau181 levels on clinician diagnostic confidence and management in memory and cognition clinics: A multi-site before-and-after study.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Analysis of second-generation epigenetic clocks reveals further associations between disproportionate biological ageing and hippocampal volume.

GeroScience·2026
Same author

Predicting accumulation and age at onset of amyloid-β from genetic risk and resilience for Alzheimer's disease.

EBioMedicine·2026
Same author

Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Genetic variation in the glymphatic pathway predicts cognition and neurodegeneration in preclinical Alzheimer's disease.

Research square·2026
Same journal

<sup>18</sup>F-NaF PET/CT Versus <sup>18</sup>F-FDG PET/CT for Baseline Mapping in Ollier Disease: A Pediatric Case.

Journal of nuclear medicine technology·2026
Same journal

Incidental Detection of Aggressive HER2-Positive Breast Cancer on <sup>99m</sup>Tc-Sestamibi Parathyroid Scintigraphy.

Journal of nuclear medicine technology·2026
Same journal

Structured Educational Tours in Hospital-Based Radiopharmaceutical Production: Balancing Safety and Learning.

Journal of nuclear medicine technology·2026
Same journal

Development of a Phantom for Evaluating Image Quality and Partial-Volume Effects in Hot and Cold Regions in Small-Animal SPECT and PET.

Journal of nuclear medicine technology·2026
Same journal

Nonuniformity in a Certified <sup>68</sup>Ge PET Cylinder Phantom: Implications for Normalization Quality Assurance.

Journal of nuclear medicine technology·2026
Same journal

Reducing Formation of Suspected Tracer Microemboli During Preparation of <sup>99m</sup>Tc-Tagged Heat-Damaged Red Blood Cells.

Journal of nuclear medicine technology·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Visualization of Amyloid &#946; Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

Brain amyloid imaging.

Christopher C Rowe1, Victor L Villemagne

  • 1Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Australia. christopher.rowe@austin.org.au

Journal of Nuclear Medicine Technology
|February 12, 2013
PubMed
Summary
This summary is machine-generated.

Positron emission tomography (PET) imaging using (18)F-labeled tracers to detect brain beta-amyloid plaques will soon aid Alzheimer disease (AD) diagnosis. This review prepares nuclear medicine physicians for interpreting these emerging amyloid imaging scans.

Related Experiment Videos

Last Updated: May 14, 2026

Visualization of Amyloid &#946; Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

Area of Science:

  • Neurology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Alzheimer disease (AD) prevalence is increasing with an aging population.
  • Early diagnosis and treatment are crucial for managing AD.
  • Brain amyloid imaging using positron emission tomography (PET) is emerging as a key diagnostic tool.

Purpose of the Study:

  • To provide nuclear medicine physicians with essential background knowledge for interpreting brain amyloid PET scans.
  • To explain the relationship between amyloid plaques and cognitive decline in AD.
  • To prepare physicians for practical training in scan interpretation.

Main Methods:

  • Review of current literature on (18)F-labeled tracers for amyloid PET imaging.
  • Discussion of image acquisition and display techniques for amyloid detection.
  • Analysis of tracer binding patterns in AD and other dementias.

Main Results:

  • (18)F-labeled tracer PET imaging for brain beta-amyloid plaques is nearing clinical availability.
  • Understanding the link between amyloid burden and cognitive status is vital.
  • Familiarity with diverse tracer binding patterns is necessary for accurate diagnosis.

Conclusions:

  • Brain amyloid PET imaging is poised to become a standard diagnostic investigation for Alzheimer disease.
  • Nuclear medicine physicians require comprehensive knowledge of amyloid imaging principles and interpretation.
  • This article serves as a foundational resource for physicians entering this specialized field.