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A novel HLA-A allele, A*31:65, was identified by sequence-based typing in a Chinese potential donor

Y-F Chen1, L Yang, Y-L Zhuang

  • 1HLA Typing Laboratory, Blood Center of Shandong Province, Jinan, China.

Tissue Antigens
|February 13, 2013
PubMed

Abstract:

A*31:65: one nucleotide change resulting in a new motif CAC at codon 84 in HLA-A.

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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