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Identification of a new HLA allele, HLA-DRB1*03:80, in a Chinese Han ethnic individual

Y Zhang1, X-M Nie, Y-L Zhuang

  • 1HLA Laboratory, Blood Center of Shandong Province, Jinan, China.

Tissue Antigens
|March 21, 2013
PubMed

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Exon Recombination02:32

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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...