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Updated: May 14, 2026

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
Published on: October 4, 2024
Intrinsic feedbacks in MAPK signaling cascades lead to bistability and oscillations
Jacques-Alexandre Sepulchre1, Alejandra C Ventura
1Institut Non Linéaire de Nice, UMR 7335 CNRS, University of Nice Sophia Antipolis, 1361 route des Lucioles, 06560 Valbonne, France. jacques-alexandre.sepulchre@inln.cnrs.fr
Abstract:
Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be quantitatively and, more importantly, qualitatively modified when this cycle is coupled to a signaling pathway as opposed to being isolated. This property was named retroactivity. These two results are studied together in this paper showing the existence of interesting phenomena--oscillations and bistability--in signaling cascades possessing at least one stage with a double-phosphorylation cycle as in MAPK cascades.
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