Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing collaborative relationships and mental health literacy to improve school behavioral health for middle school students: a randomized controlled trial.

BMC public health·2026
Same author

Clinical efficacy and safety of two highly purified human menopausal gonadotropins in women undergoing in vitro fertilization.

Reproduction & fertility·2025
Same author

IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells.

iScience·2025
Same author

IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy.

Frontiers in immunology·2024
Same author

Association between enthesitis/dactylitis resolution and patient-reported outcomes in guselkumab-treated patients with psoriatic arthritis.

Clinical rheumatology·2024
Same author

Robust anti-tumor T cell response with efficient intratumoral infiltration by nanodisc cancer immunotherapy.

Advanced therapeutics·2024

Related Experiment Video

Updated: May 14, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Th17 cell development: from the cradle to the grave.

Luis A Zúñiga1, Renu Jain, Christopher Haines

  • 1Pathway Biology, Merck Research Laboratories, Palo Alto, CA 94304-1104, USA.

Immunological Reviews
|February 15, 2013
PubMed
Summary

Naive T cells differentiate into various effector types, including T-helper 17 (Th17) cells, crucial for immunity. Interleukin-23 (IL-23) shapes Th17 cell development, including natural Th17 (nTh17) cells originating in the thymus.

More Related Videos

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Related Experiment Videos

Last Updated: May 14, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
07:12

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

Published on: April 16, 2015

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Naive T cells develop into effector phenotypes like Th17 cells in the periphery.
  • Interleukin-23 (IL-23) is critical for Th17 cell differentiation and function.
  • Emerging research indicates IL-23 also supports natural Th17 (nTh17) cell development from the thymus.

Purpose of the Study:

  • To review the differentiation and function of inducible, natural, and memory Th17 cell subsets.
  • To highlight the role of IL-23 throughout the Th17 cell lifecycle.
  • To elucidate the distinct thymic developmental pathway of nTh17 cells.

Main Methods:

  • Literature review of T cell differentiation and cytokine signaling.
  • Analysis of studies on Th17 cell subsets (inducible, natural, memory).
  • Focus on the role of IL-23 in Th17 cell biology.

Main Results:

  • Th17 cells, characterized by RORγt, IL-17, IL-22, and GM-CSF, are vital for immune responses.
  • IL-23 is a key cytokine influencing Th17 cell development and function.
  • nTh17 cells represent a distinct thymic-derived subset, separate from memory Th17 cells.

Conclusions:

  • Th17 cell subsets (inducible, natural, memory) contribute to diverse immune functions and tissue homeostasis.
  • IL-23 plays a central role in the life cycle of various Th17 cell populations.
  • Understanding nTh17 cell development offers new insights into T cell immunity.