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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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Published on: June 2, 2015

Acquired and Heritable Thrombophilia in Indian Patients With Pediatric Deep Venous Thrombosis (DVT)

Navin Pai1, Kanjaksha Ghosh1, Shrimati Shetty2

  • 1National Institute of Immunohaematology (ICMR), KEM Hospital, Mumbai, India.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|February 15, 2013
PubMed

Insights

Pediatric deep venous thrombosis (DVT) often stems from other health issues, not primarily hereditary thrombophilia. Factor V Leiden mutation is less common in children compared to adults.

Area of Science:

  • Pediatric Hematology
  • Vascular Medicine
  • Genetics

Background:

  • Deep venous thrombosis (DVT) in children presents unique etiological factors.
  • Underlying pathological conditions are frequently implicated in pediatric venous thromboembolism.
  • Hereditary thrombophilia plays a variable role across different age groups.

Purpose of the Study:

  • To analyze the prevalence and type of thrombophilia in pediatric patients with venous thrombosis.
  • To compare thrombophilia markers and thrombosis sites in children.
  • To identify risk factors for venous thrombosis in pediatric populations.

Main Methods:

  • Retrospective analysis of 285 pediatric patients diagnosed with venous thrombosis.
  • Assessment of four common thrombophilia markers: protein C, protein S, antithrombin III, and factor V Leiden (FVL) mutation.
  • Categorization of thrombosis based on anatomical site.

Main Results:

  • Hepatic and portal vein thrombosis occurred in 73% of pediatric cases.
  • Hereditary thrombophilia was identified in 15.5% of the pediatric cohort.
  • Factor V Leiden mutation was found in only 1.8% of pediatric patients, unlike its higher prevalence in adult thrombosis.

Conclusions:

  • Venous thrombosis risk factors differ significantly between pediatric and adult populations.
  • Underlying conditions are more significant drivers of DVT in children than hereditary thrombophilia.
  • Factor V Leiden mutation is not a primary contributor to pediatric venous thrombosis.

Keywords:
Budd–Chiari syndromedeep venous thrombosisinfectionportal venous thrombosisthrombophilia

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