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Updated: May 14, 2026

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration
Published on: July 31, 2013
Is rapid effect of thyroxine on GABAergic IPSCs purely postsynaptic?
Maksim Storozhuk1, Svetlana Ivanova, Lyudmila Nikolaenko
1International Center of Molecular Physiology, Bogomoletz 4, 01024 Kiev, Ukraine. maksim@biph.kiev.ua
Background:
Thyroid hormones (THs) are well known for their genomic effects but recently several studies revealed their actions as rapid modulators of membrane receptors. In particular, fast thyroxine effect on GABA(A) receptors have been reported. We addressed question whether presynaptic mechanisms can be also involved in modulation of GABAergic transmission by thyroxine.
Methods:
Using patch-clamp technique we examined fast effects of thyroxine (2 μM) on evoked GABAergic postsynaptic currents.
Results:
We found that in addition to the inhibitory effect on IPSC amplitude, thyroxine changed IPSC coefficient of variation (CV).
Conclusion:
This result suggests involvement of a presynaptic mechanism in thyroxine effect on GABAergic transmission.
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