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CO transfer factor on exercise: age and sex differences.

A H Kendrick1, G Laszlo

  • 1Respiratory Dept. Bristol Royal Infirmary, UK.

The European Respiratory Journal
|March 1, 1990
PubMed
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Age and sex significantly impact exercise-induced single-breath transfer factor (TLCO) and transfer coefficient (KCO). Lung function declines with age, with distinct sex-based differences observed even after anthropometric adjustments.

Area of Science:

  • Pulmonary Physiology
  • Exercise Physiology

Background:

  • The single-breath transfer factor (TLCO) and transfer coefficient (KCO) are key indicators of lung function.
  • Understanding how age and sex influence these parameters during exercise is crucial for accurate physiological assessment.

Purpose of the Study:

  • To investigate the effects of age and sex on TLCO and KCO during incremental exercise in healthy adults.
  • To establish relationships between TLCO/KCO and physiological parameters like oxygen consumption (VO2), cardiac frequency (fc), and workload (WL).

Main Methods:

  • Eighty healthy subjects (40 men) were divided into four age groups (20-59 years).
  • TLCO, KCO, VO2, and fc were measured at rest and during incremental exercise (up to 150W for men, 100W for women).
  • Quadratic regression analyses were used to model the relationships between lung function parameters and exercise variables.

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Main Results:

  • TLCO and KCO decreased with increasing age across all workloads and physiological measures.
  • The rate of decline in TLCO and KCO with age was quantified.
  • Men exhibited higher TLCO, while women showed higher KCO, irrespective of age and anthropometric corrections.

Conclusions:

  • Both age and sex exert significant, independent effects on TLCO and KCO during exercise.
  • These findings highlight the importance of considering age and sex when interpreting exercise-induced changes in gas transfer factor.