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Lactoferrin and necrotizing enterocolitis.

Michael P Sherman1

  • 1Division of Neonatology, Women's and Children's Hospital, University of Missouri Health System, University of Missouri, Suite 206, 404 Keene Street, Columbia, MO 65201, USA. ShermanMP@health.missouri.edu

Clinics in Perinatology
|February 19, 2013
PubMed
Summary
This summary is machine-generated.

Lactoferrin (LF), a protein abundant in breast milk, possesses antimicrobial properties that help combat bacteria and support a healthy gut microbiome. Early consumption of colostrum and milk rich in LF may prevent necrotizing enterocolitis in infants.

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Area of Science:

  • Biochemistry
  • Microbiology
  • Pediatrics

Background:

  • Lactoferrin (LF) is a key protein in human milk, belonging to the transferrin family.
  • LF and lysozyme exhibit bactericidal effects, crucial for infant health.
  • Pepsin in the stomach converts LF into lactoferricin, a potent antimicrobial peptide.

Purpose of the Study:

  • To explore the antimicrobial functions of lactoferrin.
  • To investigate the role of LF in maintaining a healthy intestinal microbiome.
  • To highlight the significance of colostrum and milk consumption for preventing necrotizing enterocolitis.

Main Methods:

  • Literature review on lactoferrin's properties and functions.
  • Analysis of LF concentration in human milk, particularly colostrum.
  • Examination of LF's role in infant gut health and disease prevention.

Main Results:

  • Lactoferrin demonstrates significant antimicrobial activity against bacteria.
  • The conversion of LF to lactoferricin enhances its antibiotic potency.
  • Highest LF concentrations are found in colostrum, suggesting its importance in early infant nutrition.

Conclusions:

  • Lactoferrin contributes to a healthy infant gut microbiome through its antimicrobial actions.
  • Early feeding of colostrum and fresh mature milk, rich in LF, is a potential strategy to prevent necrotizing enterocolitis.