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Updated: May 14, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Toll-like receptors in neonatal sepsis
Fiona M O'Hare1, R William Watson, Eleanor J Molloy
1Department of Neonatology, National Maternity Hospital, Dublin, Ireland. fionaohare@physicians.ie
Unlabelled:
Toll-like receptors are vital transmembrane receptors that initiate the innate immune response to many micro-organisms. The discovery of these receptors has improved our understanding of host-pathogen interactions, and these receptors play an important role in the pathogenesis of multiple neonatal conditions such as sepsis and brain injury. Toll-like receptors, especially TLRs 2 and 4, are associated with necrotizing enterocolitis, periventricular leukomalacia and sepsis.
Conclusion:
Toll-like receptor modulation may potentially be used as immunomodulators in the management of neonatal sepsis.
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