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Updated: May 14, 2026
12:28
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
[From Pick's disease to frontotemporal dementia]
Florence Pasquier1, Vincent Deramecourt, Florence Lebert
1Neurologie, CHRU Hôpital Salingro 59037 Lille. Florence.pasquier@chru-lille.fr
Bulletin De L'Academie Nationale De Medecine
|February 21, 2013
Summary
Frontotemporal dementias (FTD) involve behavioral and language changes due to brain degeneration. Early recognition and support are crucial, as FTD is often misdiagnosed.
Area of Science:
- Neurology
- Neuroscience
- Genetics
Context:
- Frontotemporal dementias (FTD) are characterized by progressive changes in social behavior, conduct, and language, linked to degeneration in the frontal and anterior temporal lobes.
- Clinical manifestations of FTD vary based on the specific location of the neuropathological process.
- Recent research has refined diagnostic criteria for FTD, improving specificity and sensitivity.
Purpose:
- To review current understanding of Frontotemporal Dementias (FTD).
- To highlight diagnostic challenges and recent advances in neuropathological and genetic research.
- To discuss therapeutic strategies and essential supportive care for FTD patients and their families.
Summary:
- FTD involves gradual changes in behavior and language due to frontal and temporal lobe degeneration.
- Research reveals overlaps between FTD, motor neuron disease, and parkinsonian syndromes, enhancing knowledge of FTD pathophysiology.
- While better recognized, FTD remains underdiagnosed and often mistaken for psychiatric conditions, necessitating improved healthcare professional awareness.
Impact:
- Advances in neuropathology and genetics are identifying new therapeutic targets for FTD.
- Improved recognition and diagnosis of FTD are essential for timely intervention.
- Comprehensive care, including symptomatic treatment, environmental adaptation, and caregiver support, is vital for managing FTD.
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