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Updated: May 14, 2026
06:07
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
Published on: October 6, 2022
Will it be possible to live without antiretroviral therapy?
Chiraz Hamimi1, Gianfranco Pancino, Françoise Barré-Sinoussi
1Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France.
Current Opinion in HIV and AIDS
|February 21, 2013
Summary
Certain individuals naturally control HIV infection through robust immune responses or by managing immune activation. Understanding these mechanisms is key to developing new HIV functional cure strategies.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Some individuals spontaneously control human immunodeficiency virus (HIV) infection without therapy.
- This control involves managing viral replication and/or chronic immune activation.
Purpose of the Study:
- To review insights into mechanisms of HIV control in elite controllers.
- To explore how these mechanisms inform therapeutic strategies for an HIV functional cure.
Main Methods:
- Review of recent scientific literature on HIV controllers.
- Analysis of immunological and virological data from studies on HIV-infected individuals.
Main Results:
- HIV control is associated with efficient HIV-specific CD8 T-cell responses and small viral reservoirs.
- Some patients control immune activation despite high viremia, similar to SIV-infected non-human primates.
- Therapeutic strategies targeting viral reservoirs and immune activation are emerging.
Conclusions:
- Understanding HIV control mechanisms has led to successful approaches in some patients.
- Further research is needed to generalize these findings for a broader HIV-positive population.
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