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Peripheral blood stem cell transplantation in a significant body weight difference between a smaller donor and a

Michinori Funato1, Hideo Kaneko, Hideo Sasai

  • 1Department of Pediatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|February 21, 2013
PubMed

Insights

Allogeneic stem cell transplants can be successful even when a younger, smaller sibling donates peripheral blood stem cells. This case study shows a successful transplant from a smaller brother to a larger sibling with acute myeloid leukemia.

Area of Science:

  • Pediatric Hematology Oncology
  • Transplantation Immunology

Background:

  • Allogeneic peripheral blood stem cell transplantation (PBSCT) is increasingly utilized in pediatric patients.
  • Limited data exists on the efficacy of utilizing smaller children as stem cell donors for larger recipients.

Observation:

  • A pediatric patient with relapsed acute myeloid leukemia (AML), weighing 52 kg and with blood type O, was considered for PBSCT.
  • A human leukocyte antigen (HLA)-matched sibling donor, weighing 29.9 kg and with blood type A, was selected.

Findings:

  • The case involved a successful allogeneic PBSCT procedure where a smaller sibling donor provided peripheral blood stem cells to a larger recipient with relapsed AML.
  • Despite the weight and blood type differences (donor: 29.9 kg, type A; recipient: 52 kg, type O), the transplant was performed.

Implications:

  • This case suggests that significant weight and ABO blood group differences between a smaller pediatric donor and a larger recipient do not preclude successful allogeneic PBSCT.
  • Further research is warranted to explore the broader applicability and potential benefits of utilizing smaller pediatric donors in specific transplantation scenarios.

Keywords:
Benefits of younger donorsPeripheral blood stem cell collectionPeripheral blood stem cell transplantationSafety of donorsSignificant body weight difference

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