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Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
The DNA Replication Fork01:02

The DNA Replication Fork

An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication forks, one in...
RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...

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Updated: May 13, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

RNA-templated DNA origami structures.

Masayuki Endo1, Seigi Yamamoto, Koichi Tatsumi

  • 1Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan. endo@kuchem.kyoto-u.ac.jp

Chemical Communications (Cambridge, England)
|March 1, 2013
PubMed
Summary
This summary is machine-generated.

Researchers created novel DNA origami structures using RNA templates. These RNA-templated DNA structures can form complex shapes like rectangular and tubular bundles, enabling new applications in nanotechnology.

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Last Updated: May 13, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

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Published on: May 8, 2015

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Area of Science:

  • Nanotechnology
  • Biomolecular Engineering
  • Structural Biology

Background:

  • DNA origami is a nanotechnology technique that uses self-folding properties of DNA to create nanoscale structures.
  • RNA molecules offer unique templating capabilities due to their diverse structures and chemical properties.

Purpose of the Study:

  • To develop a method for constructing DNA origami structures templated by RNA molecules.
  • To explore the formation of complex, multi-helix bundled structures using RNA templates.
  • To investigate the creation of chemically modified RNA-DNA hybrid origami structures.

Main Methods:

  • Utilized RNA transcripts as templates for DNA origami construction.
  • Employed designed DNA staple strands for annealing and folding processes.
  • Incorporated chemically modified uracils into RNA templates for hybrid structures.

Main Results:

  • Successfully constructed RNA-templated DNA origami structures.
  • Achieved folding into specific architectures: seven-helix bundled rectangular and six-helix bundled tubular structures.
  • Demonstrated the feasibility of creating modified RNA-DNA hybrid origami.

Conclusions:

  • RNA can serve as an effective template for directing the assembly of complex DNA origami nanostructures.
  • The developed method allows for the precise formation of multi-helix bundled structures with potential applications in molecular devices.
  • The incorporation of modified nucleobases opens avenues for advanced functionalization of RNA-templated DNA origami.