Related Experiment Video
Updated: May 13, 2026
13:26
Induction and Monitoring of Active Delayed Type Hypersensitivity (DTH) in Rats
Published on: July 19, 2007
[Immune reactions after DMEK, DSAEK and DALK]
1Zentrum für Augenheilkunde, Universität zu Köln. Kerpener Strasse 62, Koln.
Klinische Monatsblatter Fur Augenheilkunde
|March 1, 2013
Summary
Modern lamellar corneal transplant techniques like Descemet membrane endothelial keratoplasty (DMEK) and deep anterior lamellar keratoplasty (DALK) have nearly eliminated endothelial immune reactions, improving outcomes for corneal diseases.
Area of Science:
- Ophthalmology
- Transplantation immunology
Context:
- Endothelial immune reactions pose a significant risk following traditional corneal transplantation.
- Modern lamellar keratoplasty techniques aim to minimize immunological complications.
Purpose:
- To review the incidence, diagnosis, and therapy of endothelial immune reactions after lamellar corneal transplantation.
- To evaluate the impact of Descemet membrane endothelial keratoplasty (DMEK), Descemet stripping automated endothelial keratoplasty (DSAEK), and deep anterior lamellar keratoplasty (DALK) on these reactions.
Summary:
- Deep anterior lamellar keratoplasty (DALK) for keratoconus shows no subsequent endothelial immune reactions.
- Descemet membrane endothelial keratoplasty (DMEK) substantially lowers the risk of endothelial immune reactions in Fuchs dystrophy.
- Both DALK and DMEK utilize an avascular recipient bed, significantly reducing immunological risks.
Impact:
- Lamellar keratoplasty, particularly DALK and DMEK, represents a major advancement in reducing corneal transplant rejection.
- These techniques offer improved safety profiles for patients undergoing corneal transplantation for various conditions.
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