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Updated: May 13, 2026

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry
Published on: April 9, 2021
Fluorine-18 labeling by click chemistry: multiple probes in one pot
Lina Jia1, Zhen Cheng, Lingli Shi
1Shanghai Institute of Applied Physics (SINAP), Chinese Academy of Sciences, PR China.
Abstract:
Click chemistry has been widely applied in drug development including radiopharmaceuticals and has shown great advantages. Here we reported a novel strategy for rapid preparation of multiple (18)F labeled PET probes in one pot using the 'Click Reaction' of Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of terminal alkynes and organic azides (CuAAC). Preliminary results showed its high efficiency and potential for speeding up the preclinical screening of PET probes.
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