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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
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Concepts and practices used to develop functional PLGA-based nanoparticulate systems.

Hongkee Sah1, Laura A Thoma, Hari R Desu

  • 1College of Pharmacy, Ewha Womans University, Sedaemun-gu, Seoul, South Korea. hsah@ewha.ac.kr

International Journal of Nanomedicine
|March 6, 2013
PubMed
Summary
This summary is machine-generated.

Functional polylactide-co-glycolide (PLGA) nanoparticles overcome limitations of bare PLGA systems. Surface functionalization enhances drug delivery, improving therapeutic outcomes for targeted treatments.

Keywords:
functionalitynanoparticlesnanoparticulate dosage formspolylactide-co-glycolide

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Bare polylactide-co-glycolide (PLGA) nanoparticles exhibit limited functionality, primarily acting as drug depots or solubilizers.
  • Conventional PLGA nanoparticles face challenges such as rapid systemic clearance and lack of cell-type specificity, hindering effective in vivo drug delivery.
  • Surface functionalization and novel nanoparticulate designs are crucial for overcoming these limitations and enhancing nanoparticle performance.

Purpose of the Study:

  • To review fundamental concepts and practices in developing functional nanoparticulate dosage forms based on PLGA.
  • To explore how diverse functional PLGA-based systems can achieve therapeutic effects beyond conventional treatments.
  • To highlight the potential of advanced PLGA nanocarriers for targeted delivery of therapeutic and diagnostic agents.

Main Methods:

  • Review of recent research on surface-functionalized nanoparticles and new nanoparticulate dosage forms.
  • Analysis of diverse functional PLGA-based systems including PEGylated nanoparticles, polyplexes, polymersomes, lipid-PLGA hybrids, cell-PLGA hybrids, ligand-PLGA conjugates, and theranostics.
  • Discussion of the attributes and potential contributions of these functional systems to therapeutic outcomes.

Main Results:

  • Functionalization strategies significantly improve the in vivo performance of PLGA nanoparticles, addressing issues of clearance and targeting.
  • Various functional PLGA-based systems, such as PEGylated nanoparticles and receptor-specific conjugates, offer distinct advantages over bare nanoparticles.
  • These advanced systems demonstrate potential for selective and effective delivery of chemotherapeutic, diagnostic, and imaging agents.

Conclusions:

  • Functional PLGA-based nanoparticulate systems represent a significant advancement over conventional drug delivery methods.
  • Tailored surface modifications and novel formulations enhance the therapeutic efficacy and targeting capabilities of PLGA nanocarriers.
  • These sophisticated nanodelivery platforms are poised to revolutionize the treatment of various diseases through precise agent delivery.