[Allergic reaction induced by steroid therapy]

Area of Science:

• Allergy and Immunology
• Pharmacology
• Critical Care Medicine

Background:

• Glucocorticoids are essential medications for managing allergies and inflammatory diseases.
• Despite their benefits, glucocorticoids carry a risk of inducing hypersensitivity reactions, including anaphylaxis.
• The incidence of steroid-induced adverse reactions is reported up to 0.3%.

Observation:

• This report details an anaphylactic reaction in an 86-year-old patient.
• The patient presented with acute stridor and respiratory failure immediately following hydrocortisone administration.
• Hydrocortisone, prednisone, and methylprednisolone are frequently implicated in steroid-induced anaphylaxis.

Findings:

• Immediate post-treatment stridor and respiratory failure indicate a severe allergic response to hydrocortisone.
• The case underscores the potential for life-threatening anaphylaxis from commonly prescribed glucocorticoids.
• Risk factors and effective management strategies for steroid-induced anaphylaxis are crucial.

Implications:

• Healthcare providers must maintain a high index of suspicion for glucocorticoid-induced anaphylaxis.
• Awareness and recognition of these rare but severe reactions are vital for patient safety.
• Prompt diagnosis and management are critical for improving outcomes in patients experiencing anaphylaxis to steroids.